Costimulatory Molecules Development

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  • Published date: January 28, 2019
    • Shirley, New York, United States

In T cell signaling, at least two signals are considered integral in defining the fate of naive T cells and their competence to combat disease. Major histocompatibility complex (MHC)-peptide interactions with T cell receptor (TCR) provide the first signal in immune responses. However, while the MHC–peptide interaction with TCR is essential in determining specificity and initiating T cell activation, this process is not sufficient to determine the fate of T cells. Costimulatory and coinhibitory molecules, which are cell surface glycoprotein molecules, supply additional signal or “second signal” to T cells through antigen-presenting cells (APCs), providing context to the state of activation or inactivation that develops within the T cell. The second signal delivered is most likely a product of both costimulatory and coinhibitory influences. Positive signals result in T cell proliferation, expansion, and survival; specific cytokine release; and cytotoxic effector responses. Negative signaling results in T cell death, reduced memory responses, suppressor T cell induction, and immunosuppressive cytokine secretion.

Creative Biolabs is a world leader in the field of cancer vaccine development. With our extensive experience and advanced platform, we are therefore confident in offering the best development services for costimulatory molecules and provide attractive therapy in the antitumor armamentarium. We guarantee the finest results for our customers all over the world.

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Jerry Carter
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