Magic™ GPCR Stable Cell Lines For Antibody Function Study

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  • Published date: September 30, 2019
    • Shirley, New York, United States

Inspired by two signaling pathways involved in GPCR signaling pathways, Creative Biolabs has introduced an innovative anti-GPCR antibody function screening system in virtue of different fluorescent biosensor linked with the activity of 3 secondary messengers (cAMP, DAG, Ca2+) as well as β-arrestin. Once the particular signal pathway is activated, engineered biosensor on plasma membrane will quickly translocate into the cytosol, thus elicit obvious fluorescence changes. In contrast to conventional reporter gene assay, this strategy provides a rapid, convenient and precise alternative for function profiling of GPCR-targeting agents. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-gpcr-stable-cell-lines-for-antibody-function-study.htm .

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