Magic™ Humanized CD137 Immune Checkpoint Knock-In Mice

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  • Published date: September 30, 2019
    • Shirley, New York, United States

CD137 is one of the tumor necrosis factor (TNF) receptor family member, which is also known as TNFRSF9 and 4-1BB. CD137 is expressed on activated T cells, while to a larger extent on CD8+ than on CD4+ T cells. Additionally, CD137 is also found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. Activation with several agonists, such as cytokines (IL-2, IL-4), polyclonal activators (Con A and PHA), and cell surface molecules (anti-CD3 and anti-CD28), and promoters of Ca2+ induction and PKC activity (ionomycin and phorbol myristate acetate), can further enhance the expression of CD137. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-cd137-immune-checkpoint-knock-in-mice.htm .

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