Magic™ Humanized CD27 Immune Checkpoint Knock-In Mice

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  • Published date: September 30, 2019
    • Shirley, New York, United States

The activity of CD27 is restricted by the transient availability of its ligand CD70/TNFSF7, which is constitutively expressed on medullary thymic epithelial cells (mTECs) and dendritic cells. Apart from this, CD70/TNFSF7 is specifically expressed after immune activation, as it is found on activated DCs, B cells, conventional- and regulatory T cells and NK cells. The expression of CD70/TNFSF7 is exceedingly regulated by antigen since it is under control of PRRs, T cell and B cell antigen receptors, and its expression is further tuned by cytokines such as IL-1α, IL-12, TNFα, prostaglandin E2 and by CD28- and CD40 co-stimulation. Epithelial cells and other cell types may acquire CD70/TNFSF7 upon malignant transformation. The CD27 ligand CD70/TNFSF7 was similarly presented to promote TCR/CD3-induced proliferation of naive CD4+ and CD8+ human T cells as well as the generation of effector cells. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-cd27-immune-checkpoint-knock-in-mice.htm .

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