Magic™ Humanized CD28 Immune Checkpoint Knock-In Mice

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  • Published date: September 30, 2019
    • Shirley, New York, United States

CD28 and CTLA4 are highly homologous and compete for the same ligands [B7-1 (CD80) and B7-2 (CD86)]. The affinity of CTLA4 binding to these ligands is higher than CD28, which enables CTLA4 to compete with CD28 for ligands and suppress effector T cells responses. Recent studies have shown that CD28 and CTLA4 have opposing effects on T cell stimulation. CD28 has an activating function while CTLA4 has an inhibitory function, which is now regarded as a prototypical immune checkpoint. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-cd28-immune-checkpoint-knock-in-mice.htm

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Jerry Carter
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