Magic™ Humanized PD-1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

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  • Published date: September 30, 2019
    • Shirley, New York, United States

Programmed death-1 (PD-1) is a costimulatory receptor that belongs to the B7/CD28 family. PD-1 is expressed on numerous immune cells such as activated T cells, natural killer (NK) cells, B cells and some myeloid cells. PD-1 regulates T-cell activation by delivering a negative signal to T cells to suppress the immune response when binding to its ligands PD-L1 or PD-L2. This kind of PD-1 binding inhibits T-cell proliferation, and interferon-g (IFN-g), tumor necrosis factor-a, and IL-2 production, and decreases T-cell survival. PD-1 expression is a hallmark of “exhausted” T cells which have experienced high levels of stimulation or reduced CD4+ T-cell help. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-pd-1-ctla-4-dual-immune-checkpoint-knock-in-mice.htm .

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