Magic™ Humanized SIRPα Immune Checkpoint Knock-In Mice

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  • Published date: September 30, 2019
    • Shirley, New York, United States

In a wide variety of preclinical models, therapies that block the CD47/SIRPα axis stimulate phagocytosis of cancer cells in vitro and anti-tumor immune responses in vivo. Nowadays, many therapeutics targeting the CD47/SIRPα axis are under preclinical and clinical investigation. As a crucial regulator of macrophage phagocytosis and activation, the potential applications of CD47/SIRPα blocking therapies extend beyond human cancer. They may also be utilized for the treatment of infectious disease, conditioning for stem cell transplant, and many other clinical indications. With years of experience, Creative Biolabs has successfully established a series of well-characterized Magic™ “humanized” animal models, especially for SIRPα. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-sirpa-immune-checkpoint-knock-in-mice.htm

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Jerry Carter
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