Magic™ Humanized TNF-α Immune Checkpoint Knock-In Mice

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  • Published date: September 30, 2019
    • Shirley, New York, United States

Targeted immune checkpoint blockade augments anti-tumor immunity and induces durable responses in patients with melanoma and other solid tumors. Tumor necrosis factor (TNF or TNF-α) is a major pro-inflammatory cytokine involved in early The primary concept of cancer immunotherapy is to enable the immune system to detect neoplastic growth and to either prevent carcinogenesis and/or reject transformed cells with a potential for malignant tumor growth. Tumor necrosis factor, also known as TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin, is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. The TNF gene is localized in the highly polymorphic region of human chromosome 6p21. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-tnf-immune-checkpoint-knock-in-mice.htm .

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