Suspension Culture for Avian Influenza Vaccine Production

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  • Published date: January 28, 2019
    • Shirley, New York , United States

In recent years, animal cell culture technology has gradually replaced the traditional chick embryo production process for influenza vaccine production. Currently, most of cells applied for influenza vaccine production are adherent and grown as monolayers. As a result, large-scale culture processes mainly rely on cultivating adherent cells on microcarriers in serum-containing medium. For vaccine production, supplementation of serum brings about many problems:

Creative Biolabs has developed a MDCK suspension cell line in a serum-free medium. It is found that our serum-free medium supported the stable subculture and growth of both adherent and suspension cells. The growth kinetics in serum-free media are comparable to the growth kinetics in serum-containing media. Although the virus production of adherent cells in both media is similar, suspension culture in serum-free media shows a higher virus yield than adherent cells in serum-containing media. These show the great potential of this suspended MDCK cell line in serum-free media for influenza vaccine production.

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Jerry Carter
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