Toll-like Receptor 9 Agonists Development

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  • Published date: December 26, 2018
    • Shirley, New York, United States

Creative Biolabs is a world leader in the field of cancer vaccine development. We provide quality Toll-like receptor 9 (TLR9) agonists development services for activating immune cells and their respective controls, with dedicated support from our experts in Creative Biolabs.

Several evidences suggest that early production of type I interferons, and induction of costimulatory molecule expression on dendritic cells, may be essential for the generation of durable and effective antitumor immunity. One way to accomplish this goal is through the induction of a Th1-like innate immune response, similar to what is generated in response to intracellular infections. The family of toll-like receptors (TLRs) appears to play a pivotal role in the generation of different classes of innate immune responses, by differential detection of conserved pathogen-expressed molecules. TLR3,7,8,9 are expressed within the endosomal compartments of some innate immune cells, where they appear to be “looking inward” to detect nucleic acid components of intracellular pathogens. Activation of these endosomal TLRs can induce strong Th1-like immune activation, with the secretion of type I IFN and strong CD8+ T cell responses. In particular, the targeting of TLR9 has emerged as a powerful tool in the generation of Th1 adaptive immunity and has shown promise for enhancing the efficacy of cancer vaccination.

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Jerry Carter
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