Biological Sciences

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  • Stapled Peptide Design

    Stapled Peptide Design

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Peptide stapling is a strategy for constraining short peptides typically in an alpha-helical conformation. Stapling is carried out by covalently linking the side-chains of two amino acids, thereby forming a peptide macrocycle. Peptide “stapling” via ...

  • Peptide Library Design

    Peptide Library Design

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Our technical and applications support team can offer advice on library design and experimental set up and analysis. Relating to design, we can advise on the best overlap or offset of peptides to be used in your target application, and then using you...

  • De novo Peptide Design

    De novo Peptide Design

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    De novo design is an attractive approach for constructing designed peptides with predetermined structures and functions. Creative Peptides provides de novo design related services for peptides engineering, including peptides structure prediction, pep...

  • Peptide Design

    Peptide Design

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Interested in the use of biologically active proteins and peptides as potential therapeutic agents has grown dramatically in recent years. Although many meaningful studies can be performed, it is important to consider several factors such as the leng...

  • Cyclic Peptide synthesis

    Cyclic Peptide synthesis

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Cyclic peptide compounds are a class of cyclic compounds with special structure, widely biological activity and unique mechanism of action, which play an important role in natural products. Cyclic peptides are compounds of stable and uniform conforma...

  • Cyclic Peptides

    Cyclic Peptides

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Cyclic peptide compounds are a class of cyclic compounds with special structure, widely biological activity and unique mechanism of action, which play an important role in natural products. Cyclic peptides are compounds of stable and uniform conforma...

  • Post-translational Modification

    Post-translational Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Post-translational modifications (PTMs) are changes to proteins or peptides that are catalyzed by enzymes after completion of ribosomal translation and it generally have a positive impact on peptide activity. PTMs play an important role in virtually ...

  • Peptide PEGylation

    Peptide PEGylation

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    It has long been a dream in medicine and pharmacy to use peptides and proteins as drugs. The driving force for this interest is the ability of these compounds to eliminate toxic or overproduced compounds in the body and to mimic endogenous hormones, ...

  • Amino Acids Modification

    Amino Acids Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Chemical modifications of peptides introduced strategically at potential enzymatic cleavage sites may dramatically increase the in vivo stability of peptide drug candidates. One simple approach to stabilizing a peptide is to modify the side-chains of...

  • Peptide C-Terminal Modification

    Peptide C-Terminal Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    The posttranslational modification of eukaryotic proteins by the addition of isoprenyl lipids at their C-termimi was first observed in the 1970s and 1980s. Since then, more than a hundred proteins have been shown to be modified by C15 farnesyl or C20...

  • Peptide N-Terminal Modification

    Peptide N-Terminal Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Although many of the most widely recognized post-translational modifications are characteristic of secretory or cell-surface proteins, most proteins, whatever their ultimate cellular desination, undergo some modification. For proteins synthesized com...

  • Peptide Modification

    Peptide Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Peptide chemists have a myriad of approaches available to optimize lead peptide structures for activity, potency and the desired selectivity for the target of interest. Thus multiple modifications and/or longer-range structural features (e.g. cycliza...