Cryo-Electron Microscopy

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  • Published date: November 28, 2019
    • Shirley, New York, United States

Cryo-electron microscopy is widely known as cryo-EM or electron cryomicroscopy, and it's a form of transmission electron microscopy (TEM). Usually, the samples are researched at cryogenic temperatures when using cryo-EM, which is gradually turning into a popular tool to investigate the formation of cells, viruses and protein fittings at molecular resolution. What's more, cryo-EM density maps are being commonly combined with NMR spectroscopy and X-ray crystallography. Therefore, atomic-resolution patterns of intricate, action molecular assemblies can be accomplished. Unlike X-ray crystallography, which needs to crystallize the specimen, cryo-EM enables the observation of specimens in their natural state. In a traditional cryo-EM, the image contrast of such phase objects is mostly produced by a combination of lens aberration and defocus. In frequency space, the data are oriented by the sinusoidal contrast transfer function (CTF) and are damped by exponential envelope functions, inducing poor contrast at low frequency, a fall-off in the signal at high frequency, and the reduction of information at the nodes of the CTF. .

Jerry Carter
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