Fear Conditioning Test

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  • Published date: November 28, 2019
    • Shirley, New York, United States

In a conditioning context, administration of a footshock (US) is paired with a tone (CS) in a certain test situation. Animals are placed in a box enclosure and receive multiple exposures of CS-US pairing (usually 1-5 times). Following an interval that is an independent variable for memory retention (usually >24 h for assessment of long-term memory), test animals are placed back in the original context where they received the CS-US exposures during the training session, as a conditioned context. If the test animals acquire an association of the US with a context (the box enclosure), they will demonstrate freezing responses to the context in the absence of CS co-exposure. Freezing is a species-specific response to fear, which has been defined as complete immobility with the exception of breathing. https://www.creative-biolabs.com/drug-discovery/therapeutics/fear-conditioning-test.htm .

Jerry Carter
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