In Vivo Fitness Assessment of Drug Candidates

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  • Published date: November 28, 2019
    • Shirley, New York, United States

Unspecific binding of drug candidates to other proteins is investigated in vitro using the protein microarray technique developed by our developability assessment groups. The objective of this assay is to provide a multitude of protein epitopes for the drug candidates and assess if the binding is restricted to the specifically designed target or not. In short, hundreds of different human proteins are respectively spotted on a nitrocellulose-coated surface, together with the binding target (antigen). In the best case, the tested candidate will only bind to its target. Problematic candidates may show binding affinities to both the target antigen and some of the other spotted proteins, an undesirable result that may influence the candidate ranking in the lead selection. https://www.creative-biolabs.com/drug-discovery/therapeutics/in-vivo-fitness-assessment-of-drug-candidates.htm

Jerry Carter
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