Magic™ Humanized CSF1R Immune Checkpoint Knock-In Mice

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  • Published date: September 30, 2019
    • Shirley, New York, United States

Colony-stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 (Cluster of Differentiation 115), belongs to the type III protein tyrosine kinase receptor family and is a single pass type I membrane protein encoded by the CSF1R gene (also known as c-FMS) in human. CSF1R acts as the receptor for colony stimulating factor 1 (CSF1), which is a cytokine that controls the production, differentiation, and function of macrophages. Macrophages are known as a highly plastic cell type that adjusts to the specific stromal environment present in malignant tumors, characterized by low oxygen pressure, tissue necrosis, and high concentrations of lactate and pyruvate. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-csf1r-immune-checkpoint-knock-in-mice.htm .

Jerry Carter
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