Peptide C-Terminal Modification

  • Check with publisher
  • Published date: July 18, 2019
    • Shirley, New York, United States

The posttranslational modification of eukaryotic proteins by the addition of isoprenyl lipids at their C-termimi was first observed in the 1970s and 1980s. Since then, more than a hundred proteins have been shown to be modified by C15 farnesyl or C20 geranylgeranyl groups, including most members of the Ras, Rho, and Rab familied of G proteins. The C-terminal of the peptide is synthesized as an amide to neutralize negative charge created by the C-terminal COOH. This modification is added to prevent enzyme degradation, to mimic native proteins, and in some cases to remove hydrogen bonding at the C-terminal of the peptides which may interfere with the assays. https://www.creative-peptides.com/services/peptide-c-terminal-modification.html

Cathy Miller
0 votes

Useful information

  • Avoid scams by acting locally or paying with PayPal
  • Never pay with Western Union, Moneygram or other anonymous payment services
  • Don't buy or sell outside of your country. Don't accept cashier cheques from outside your country
  • This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"

Related listings

  • Peptide N-Terminal Modification

    Peptide N-Terminal Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Although many of the most widely recognized post-translational modifications are characteristic of secretory or cell-surface proteins, most proteins, whatever their ultimate cellular desination, undergo some modification. For proteins synthesized com...

  • Peptide Modification

    Peptide Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Peptide chemists have a myriad of approaches available to optimize lead peptide structures for activity, potency and the desired selectivity for the target of interest. Thus multiple modifications and/or longer-range structural features (e.g. cycliza...

  • Epitope Mapping

    Epitope Mapping

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Epitope Mapping is an essential aspect in the discovery and development of diagnostic and therapeutic antibodies. It can aid in the selection of optimized therapeutic MAbs, elucidate cancer-specific epitope markers, and define the protective (and in ...