Peptide PEGylation

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  • Published date: July 18, 2019
    • Shirley, New York, United States

It has long been a dream in medicine and pharmacy to use peptides and proteins as drugs. The driving force for this interest is the ability of these compounds to eliminate toxic or overproduced compounds in the body and to mimic endogenous hormones, cytokines and antibodies. However, there is a serious challenge which is to deliver the molecules to the desired bodily target. Many approaches to enhancing protein delivery have been examined, including protein entrapment in insoluble matrices and liposomes and immobilization onto polymer resins for use with extracorporeal shunts through which blood could flow. By far the most successful approach has been to mask the protein surface by covalent coupling of soluble poly (ethylene glycol) (PEG) or, as it has been known, “PEGylation”. https://www.creative-peptides.com/services/peptide-pegylation.html

Cathy Miller
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