Peptide Prenylation

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  • Published date: July 18, 2019
    • Shirley, New York, United States

Prenylation (also known as isoprenylation or lipidation) is one of the common post-translational peptide modifications, which involves the addition of a farnesyl (C15) or geranylgeranyl (C20) isoprenoid moiety onto a cysteine residue located near the carboxyl terminal of a peptide. These chemical reactions were catalyzed by farneyl transferase (FTase) and geranylgeranyltransferase (GGTases), respectively. Proteins modified by isoprenylation play an important role in signal transduction in vivo. The role of Ras superfamily guanosine triphosphaterase (GTPases) in tumorigenesis and development has attracted wide attention. https://www.creative-peptides.com/services/peptide-prenylation.html

Cathy Miller
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