Post-translational Modification

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  • Published date: July 18, 2019
    • Shirley, New York, United States

Post-translational modifications (PTMs) are changes to proteins or peptides that are catalyzed by enzymes after completion of ribosomal translation and it generally have a positive impact on peptide activity. PTMs play an important role in virtually all biological processes, therefore, the synthesis of PTM peptides is crucial for many projects.

PTMs alter the physicochemical properties of the peptide by altering the electrostatic charge, hydrophilicity, and conformation, thereby modulating their ability to specifically bind to the protein of interest. Some nascent peptide chains can be directly folded into the final three-dimensional structure after being released from the ribosome, but in most cases, the nascent peptide undergoes a series of processing modifications to function. In general, post-translational modifications are for functional needs, and in another case, the need to fold into a natural conformation.

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Cathy Miller
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