Sleeping Beauty Transposon System

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  • Published date: November 28, 2019
    • Shirley, New York, United States

Sleeping Beauty (SB) transposon is a synthetic transposon of the Tc1-like mariner family. It was originally discovered in salmon, where it had been silenced through evolution and was then reconstructed by investigators based on molecular phylogenetic data to recover its ability to transpose the genome. The first functional version of SB transposon is SB10, which was so named because the reconstruction process required ten major steps. Thereafter, continued efforts have been made by researchers in order to improve its ability of gene transfer. As a result, a novel SB transposase, SB100X, which shows high efficiency of stable gene transfer comparable to stable transduction efficiencies of integrating viral vectors, was developed to greatly boost its research application. https://www.creative-biolabs.com/drug-discovery/therapeutics/sleeping-beauty-transposon-system.htm

Jerry Carter
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