Unusual Amino Acids Modification

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  • Published date: July 18, 2019
    • Shirley, New York, United States

At present, the number of endogenous and exogenous bioactive peptides under study is rapidly increasing, and most of these peptides are easily to be degraded by enzymes, which will greatly reduce the therapeutic effect. These peptides can usually be converted to more resistant molecules by making the necessary modifications.

Unusual amino acids are not naturally encoded amino acids. They can be naturally produced by post-translation of plants or bacteria, or chemically synthesized. Peptides modified by these amino acids tend to exhibit unique biological activities and are often included in therapeutic peptide ligands to provide pharmacological activity and potency of the peptides.

Creative Peptides provides the unusual amino acids modified peptides are:
• Good receptor binding ability
• Improved selectivity
• Modify activity (agonists and antagonists)
• Increase in vivo half-life
• Enhance transport across cell membranes


Cathy Miller
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