Apoptosis and Programmed Cell Death Assessment

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  • Published date: October 30, 2019
    • Shirley, New York, United States

Apoptosis is a type of programmed cell death (PCD), which is defined as a highly regulated process of cell elimination. Key events of apoptotic cells involve cell shrinking, nuclear and chromosomal fragmentation, PARP cleavage, etc. Two major pathways can elicit cell apoptosis, the intrinsic (or mitochondrial) pathway, and extrinsic (or death receptor) pathway. Given its crucial role in the individual development and homeostasis maintenance of all multicellular organisms, many of the widely-used drugs are intended to interfere with apoptosis process to deliver clinical effects, especially antibodies. Therapeutic antibodies can specifically bind to target cells, either triggering direct killing by apoptosis (e.g. anti-cancer agents) or inhibiting aberrant apoptosis (e.g. neurodegenerative or autoimmune disease therapies). Since apoptosis is a complex, highly dynamic process involving a variety of parameters that overlap with other mechanisms of action, one major key of determining the participation of apoptosis by either intrinsic or extrinsic pathway is to integrate the results of multiple assays. In that effort, Creative Biolabs has established a panel of well-validated assay formats to help our clients better outline the apoptosis MOA of their antibody candidates. https://www.creative-biolabs.com/drug-discovery/therapeutics/apoptosis-and-programmed-cell-death-assessment.htm .

Jerry Carter
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