Aqueous Solubility

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  • Published date: January 15, 2020
    • Shirley, New York, United States

Solubility refers to the phenomenon that solute dissolving in a solvent to give a homogeneous system. A drug needs to dissolve in the systemic circulation and achieves desired concentration to produce a desirable pharmacological response. Low aqueous solubility leads to many potential complications. For instance, in biochemical-based assays and cell-based assays, low solubility may lead compounds precipitate from screening buffer which may create a high risk of erroneous results, costly setbacks, and false leads. In the in vivo studies, even when the drug is absorbed, solubility declines may result in low bioavailability for animals as well. Besides, undissolved compounds always highly bind to plasma proteins, which largely slow down the tissue distribution and even result in drug toxicity. .

Jerry Carter
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