Conditioned Place Preference

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  • Published date: October 30, 2019
    • Shirley, New York, United States

Conditioned place preference (CPP) is a procedure commonly used to assess the rewarding effects of a stimulus by measuring increased approach and contact behaviors. The popularity of this procedure in the drug abuse field attributes to several advantages, including the simple methodology, inexpensive equipment, and many other advantages. Creative Biolabs utilizes this standard preclinical behavioral model to assess the abuse potential of drug candidates.

Conditioned place preference (CPP) is based on principles of Pavlovian classical conditioning, where the effect of the drug administered serves as the unconditioned stimulus (US) and is paired with the initially neutral environmental cues of the shuttle box compartment - after several pairings as stated in this section, these neutral environmental cues become associated with the rewarding effects of the drug and acquire secondary motivational properties. The drug-paired compartment then becomes the positive conditioned stimulus (CS+) that evokes a conditioned motivational response and elicits approach and contact behavior during the subsequent drug-free test session. https://www.creative-biolabs.com/drug-discovery/therapeutics/conditioned-place-preference.htm .

Jerry Carter
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