CYP Investigation

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  • Published date: January 15, 2020
    • Shirley, New York, United States

A drug-drug interaction occurs when two or more drugs are administrated simultaneously. Certain components of one drug may exert inducing or inhibiting effects on the metabolism of another drug by interfering the relevant enzymes, thus causing drug inefficacy or toxic adverse effects. Cytochrome 450 (CYP) enzymes, in particular, represent the major enzyme for metabolizing the bulk of known drugs in human. CYP family has multiple members and broad substrate specificity, which makes them prone to interference. Due to the pivotal and complicated role of CYP in drug metabolism, detailed CYP assessing profiles are strictly required by FDA and EMA to validate inhibiting or inducing properties of new chemical entities (NCE) in the early developing stage. To address this issue, Creative Biolabs provides integrated testing services to help researchers fully understand CYP-related characteristics. .

Jerry Carter
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