Drug Distribution

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  • Published date: January 15, 2020
    • Shirley, New York, United States

Proteins in blood can greatly influence the drug distribution in tissues. They influence a drug distributes from blood into tissues as well as from tissues to action sites. Only drugs that are unbound to components in the blood are free to diffuse across the cell membranes into the action sites. Creative Biolabs performs three “gold standard” methods for PPB evaluation which include equilibrium dialysis, ultrafiltration and ultracentrifugation. We provide 3 different plasma concentrations (10% plasma, 50% plasma and 100% plasma) to perform the PPB evaluation depending on your budget and compound characteristics. LC-MS/MS quantification is used to analyze the results. https://www.creative-biolabs.com/drug-discovery/therapeutics/drug-distribution.htm .

Jerry Carter
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