Elevated Plus Maze Test

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  • Published date: December 28, 2019
    • Shirley, New York, United States

On the test day, rats or mice are placed at the junction of the four arms of the maze, facing an open arm. They prefer to stay in the closed arms than the open arms. The number of entries into the open arms and the time spent in each arm are recorded by a video-tracking system as the index of anxiety. This test is sensitive to both anxiolytics as well as anxiogenics and has been validated for both rats and mice. Clinically effective anxiolytic drugs specifically increase, and anxiogenic drugs specifically decrease, the number of entries into the open arms and the time spent there. Other ethological measures that can be observed in rodents in the maze are the number of rears, head dips, fecal boli, freezing or stretched-attend postures. https://www.creative-biolabs.com/drug-discovery/therapeutics/elevated-plus-maze-test.htm .

Jerry Carter
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