Forced Swim Test

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  • Published date: December 28, 2019
    • Shirley, New York, United States

The FST was developed in 1978 by Porsolt and his colleagues as a model for predicting the clinical efficacy. In practice, rats or mice are placed in a cylinder filled with water during the test session. The tank is transparent and usually made of Plexiglass. The animal will swim in the water looking for an escape route. After some time, the animal may stop swimming and develop a behavioral despair that is characterized by immobility except for small movements needed to remain afloat. The animal's behavior is recorded and the duration of immobility as well as struggling and swimming is measured. Increased immobility (floating) is interpreted as a behavioral correlate of negative mood, representing a kind of depression in the animal. After treatment with antidepressants, the animals will actively execute escape-directed behaviors for a longer duration than the control animals administered with normal saline solutions. https://www.creative-biolabs.com/drug-discovery/therapeutics/forced-swim-test.htm .

Jerry Carter
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