Humanized BLT Mice

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  • Published date: February 11, 2020
    • Shirley, New York, United States

Transplantation of human hematopoietic stem cells into severe combined immunodeficient (SCID) mice leads to long-term engraftment and systemic reconstitution with human progenitor, B, and myeloid cells, but interestedly, human T cells are rarely present in any tissue. While the implantation of SCID mice with human fetal thymus and liver (SCID-hu thy/liv mice) permits the development of abundant thymocytes that are localized in the human organoid implant, there is minimal systemic repopulation with human T cells. The BLT mouse is a modification of the SCID-Hu model which was developed by Joseph McCune in the early 1900s. Humanized BLT SCID mouse models are established by co-implanting human fetal liver and autologous thymus fragments under the renal capsule of an immunodeficient mouse and then, either before or after preconditioning, human HSCs isolated from the same fetal liver are injected intravenously to engraft the bone marrow. As in the Hu-SRC-SCID model, all lineages of human hematopoietic cells develop. https://www.creative-biolabs.com/drug-discovery/therapeutics/humanized-blt-mice.htm .

Jerry Carter
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