Indomethacin-Induced Rodent Inflammation in Small Intestine

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  • Published date: February 11, 2020
    • Shirley, New York, United States

Indomethacin is a nonsteroidal drug with anti-inflammatory, anti-pyretic and analgesic properties. It is commonly used to decrease the fever, pain and other effects caused by inflammation. While NSAIDs are widely used in clinical medicine, their use is reported to be associated with a broad spectrum of adverse reactions, including increased intestinal permeability, the reduction of intestinal mucus and microcirculatory disturbances accompanying abnormally increased intestinal motility. These changes allow luminal substances, such as bile acid and intestinal bacteria, access to the mucosa, thereby leading to inflammation through infiltration of neutrophils, upregulation of inflammatory cytokines, and the production of reactive oxygen species. https://www.creative-biolabs.com/drug-discovery/therapeutics/indomethacin-induced-rodent-inflammation-in-small-intestine.htm .

Jerry Carter
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