Interference with Fungal Cell Membrane

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  • Published date: October 30, 2019
    • Shirley, New York, United States

The emerging technology of whole-genome sequencing enables exploration of therapeutic targets against pathogenic fungi to a previously unprecedented extent. However, no matter in the past or present, fungal cell membrane has always been a predominant target, directly or indirectly. Like all eukaryotes, the fungal cell membrane is organized as a phospholipid bilayer with multiple transmembrane proteins. In fungi, the primary membrane sterol is ergosterol, which is unique in contrast to animals. There located various functional proteins, such as enzymes, proton pumps, and ion transporters, on the membrane surface, essential for cell permeability, signal transduction, and cell wall morphogenesis. https://www.creative-biolabs.com/drug-discovery/therapeutics/interference-with-fungal-cell-membrane.htm .

Jerry Carter
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