Light/Dark Box Test

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  • Published date: October 30, 2019
    • Shirley, New York, United States

Creative Biolabs conducts a battery of anxiety behavioral tests to evaluate the potential therapeutic value and the anxiolytic activity of novel compounds. Specifically, the light/dark box test (LDB) is based on the innate aversion of rodents to brightly illuminated areas and on the spontaneous exploratory behavior of rodents in response to mild stressors, that is, novel environment and light.

The LDB test is a popular animal model used in pharmacology to assay unconditioned anxiety response in rodents. The LDB apparatus has two compartments. The large light compartment (2/3 of the box) is brightly lit and open, while the small dark compartment (1/3 of the box) is covered and dark. A door of 7 cm connects the two compartments. Rodents are placed in the middle of the brightly illuminated chamber and are allowed to move freely between the two chambers. They prefer darker areas, however, when presented in a novel environment, they have a tendency to explore. These two conflicting emotions lead to observable anxiety-like symptoms. When rodents are injected with anxiolytic drugs, time spent in the light compartment will increase. But when anxiogenic drugs are injected, more time is spent in the dark compartment. https://www.creative-biolabs.com/drug-discovery/therapeutics/light-dark-box-test.htm .

Jerry Carter
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