Lipophilicity

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  • Published date: January 15, 2020
    • Shirley, New York, United States

Shake-flask procedure is a simple extraction in octanol/water system under shaking. After equilibrium between all interacting components is attained, samples are collected from both phases, and concentrations in each phase are quantified with LC-MS/MS. The partition coefficient depends on the relative solubility of a substrate in a polar and non-polar solvent. https://www.creative-biolabs.com/drug-discovery/therapeutics/lipophilicity.htm .

Jerry Carter
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