Magic™ DAG-activated GPCR Stable Cell Lines

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  • Published date: February 11, 2020
    • Shirley, New York, United States

Multiple G-protein isoforms play vital roles in signal transduction, the Gq is a subtype of G-protein alpha subunits and involved in the activation of the phosphatidylinositol signaling pathway. Gq protein can activate phospholipase C (PLC) that cleaves a phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 is released into the cytosol while DAG still bounds to the membrane. IP3 then diffuses through the cytosol to bind to IP3 receptors, especially calcium channels in the endoplasmic reticulum (ER). These channels are specific to calcium and only allow the passage of calcium to move through. This will subsequently lead to an increase of cytosolic concentration of calcium, resulting in a cascade of cellular biophysical activities. DAG pathway plays an important part in a wide variety of human bodily processes. For example, thrombin receptors in platelets rely on this pathway to promote blood clotting. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-dag-activated-gpcr-stable-cell-lines.htm

Jerry Carter
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