Magic™ Humanized CD3E Immune Checkpoint Knock-In Mice

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  • Published date: September 30, 2019
    • Shirley, New York, United States

Signals transduced by the TCR initiate a wide range of mature T cell responses. Signaling by the TCR and its precursor, the pre-TCR, are also involved in the thymocyte development and selection. And the TCR signal transduction is mediated by the ITAM (immunoreceptor tyrosine-based activation motifs). Among these, CD3-epsilon (CD3E)-mediated signals are supposed to be of significant importance in T cell development. Therapeutic approaches targeted CD3E is now involved in the development of the novel immune-modulating treatment for various diseases. Currently, Creative Biolabs is proud to offer the humanized CD3E knock-in mice, with customized technical support for your drug discovery studies. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-cd3e-immune-checkpoint-knock-in-mice.htm

Jerry Carter
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