Magic™ Humanized ICOS Immune Checkpoint Knock-In Mice

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  • Published date: February 11, 2020
    • Shirley, New York, United States

ICOS (Inducible T-cell co-stimulator), also known as CD278, is a CD28-superfamily costimulatory molecule that is expressed on activated T cells as well as regulatory T cells. It is encoded by the ICOS gene. ICOS forms homodimers and plays a critical role in cell-cell signaling, immune responses, and regulation of cell proliferation, particularly for the survival and function of T cells, Th2 cell differentiation and for lung inflammatory responses. When interacts with its ligand ICOSL, ICOS can promote T cell production of several cytokines including IL-10, IL-4, IL-5, IFNg, and IL-17, depending on which cell type the effect dominates. Recently, it has been reported that the ICOS mediates interaction between tumor-infiltrating CD4C T cells and plasmacytoid dendritic cells (pDCs), which leads to the amplification of regulatory T cells (Tregs) and interleukin-10 secretion, then Tregs and pDCs that infiltrate primary breast tumors impair patient survival. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-icos-immune-checkpoint-knock-in-mice.htm .

Jerry Carter
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