Magic™ Humanized Immune Checkpoint Mice

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  • Published date: October 30, 2019
    • Shirley, New York, United States

As a leading innovator as well as a long-term dedicated service provider, Creative Biolabs has successfully launched, commercialized and optimized an exclusive Magic™ therapeutic antibody discovery platform using a variety of state-of-the-art technologies. Particularly, we now provide specialty human immune checkpoint knock-in mice to facilitate diverse immunotherapy development for our worldwide clients.

Tumor cells have multiple mechanisms to escape from host immune surveillance and elimination. One major evading mechanism is to interfere with costimulatory/inhibitory signal balance in the process of TCR activation, which can effectively induce immune suppression. This is achieved by a group of membrane proteins expressing on immune effector cells (e.g. T/B cell, NK cell). Extensive research and preclinical/clinical data highlight the promising therapeutic potential of monoclonal antibodies against those “checkpoints” to re-motivate the immune system to destroy tumors. Recently, they have gained increasing research interest, and many immune checkpoint blockers are approved by FDA or in late clinical trials. https://www.creative-biolabs.com/drug-discovery/therapeutics/humanized-immune-checkpoint-mice.htm .

Jerry Carter
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