Magic™ Humanized PD-1/4-1BB Dual Immune Checkpoint Knock-In Mice

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  • Published date: February 11, 2020
    • Shirley, New York, United States

4-1BB (also known as TNFRSF9 and CD137) belongs to the TNF receptor family, which includes multiple T cell co-stimulatory receptors that have been targeted with agonist antibodies including GITR, CD40, CD27, HVEM, LIGHT, APRIL, and TWEAK. 4-1BB plays a crucial role in sustaining effective T cell immune responses and in generating immunological memory. The expression profile of 4-1BB, as well as its unique ability to enhance robust effector responses in multiple subsets of lymphocytes relevant for tumor immunity, makes 4-1BB a uniquely appealing target for immunotherapy. Anti-4-1BB agonist has been investigated extensively in preclinical studies to treat cancer when combined with other immunomodulatory antibodies. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-pd-1-4-1bb-dual-immune-checkpoint-knock-in-mice.htm

Jerry Carter
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