Magic™ Humanized PD-1/BTLA Dual Immune Checkpoint Knock-In Mice

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  • Published date: February 11, 2020
    • Shirley, New York, United States

Checkpoint programmed death-1 (PD-1)/programmed cell death ligands (PD-Ls) have been identified as negative immunoregulatory molecules that promote immune evasion of tumor cells. Anti-PD1 therapies show a significant improvement in response to many standards of care regimens, but there is a significant need to further increase cancer patient responses. Recently, several clinical studies have shown improved response rate when combining anti-PD1 and anti-BTLA therapies. B- and T-cell lymphocyte attenuator (BTLA), also been designated as CD272, is an immunoglobulin-like protein. BTLA belongs to CD28 family and is structurally similar to cytotoxic T lymphocyte activation antigen (CTLA)-4 and programmed death (PD)-1. BTLA is an inhibitory co-receptor which modulates T cell function and is a marker of “exhausted” T cells. The inhibitory signal mediated by BTLA is initiated following engagement with herpesvirus entry mediator (HVEM), a ubiquitous receptor that is highly expressed on malignant cells. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-pd-1-btla-dual-immune-checkpoint-knock-in-mice.htm

Jerry Carter
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