Magic™ Humanized PD-1/LAG-3 Dual Immune Checkpoint Knock-In Mice

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  • Published date: February 11, 2020
    • Shirley, New York, United States

Programmed death-1 (PD-1) is a type I transmembrane protein that expressed on activated T cells as well as other immune cells including natural killer (NK) cells, B cells, and some myeloid cells. As an inhibitory receptor, PD-1 has two known ligands, programmed cell death protein 1 ligand 1 (PD-L1; also known as B7H1 and CD274) and PD-L2 (also known as B7DC and CD273), which are often overexpressed on tumor cells. The interactions of PD-1 and its ligands deliver a negative signal to T cells to suppress the immune response. T cells express PD-1 only following activation when it functions to limit the effector phase of T cell differentiation. PD-1 plays a crucial role in tolerance to self-antigens and can also function as a ‘rheostat' that modulates T cell responses. Chronic infection models have shown that blocking PD1 interactions can reverse T cell exhaustion. Tumors can evade immune response by signaling through PD1; therefore, blocking PD1 signaling pathway can induce an anti-tumor response. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-pd-1-lag-3-dual-immune-checkpoint-knock-in-mice.htm .

Jerry Carter
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