Magic™ Humanized VEGI Immune Checkpoint Knock-In Mice

  • Check with publisher
  • Published date: February 11, 2020
    • Shirley, New York, United States

Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is an anti-angiogenic protein which is coded by the TNFSF15 gene. It has a carboxyl-terminal which is present on the exterior of the cell surface, as well as a transmembrane domain and a short cytoplasmic tail. VEGI is one of the tumor necrosis factor (ligand) superfamily, where it is member 15; its ligand is TNFRSF25, which is also known as death receptor 3 (DR3) and is a newly recognized immune-activating receptor. VEGI is the sole known ligand for death receptor 3, and it can also be recognized by decoy receptor 3. VEGI induces apoptosis specifically on endothelial cells and has been demonstrated to be an inhibitor of tumor angiogenesis in animal models. Like other death ligands, VEGI activates both the NF-kB and apoptotic pathways in the target cells. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-vegi-immune-checkpoint-knock-in-mice.htm .

Jerry Carter
0 votes

Useful information

  • Avoid scams by acting locally or paying with PayPal
  • Never pay with Western Union, Moneygram or other anonymous payment services
  • Don't buy or sell outside of your country. Don't accept cashier cheques from outside your country
  • This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"

Related listings

  • Magic™ Humanized ICOS Immune Checkpoint Knock-In Mice

    Magic™ Humanized ICOS Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    ICOS (Inducible T-cell co-stimulator), also known as CD278, is a CD28-superfamily costimulatory molecule that is expressed on activated T cells as well as regulatory T cells. It is encoded by the ICOS gene. ICOS forms homodimers and plays a critical ...

  • Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    The therapy of using monoclonal antibodies against inhibitory receptors on immune cells, termed immune-checkpoint blockade, for the treatment of human cancer has gained a great deal of attention among clinicians, scientists, and patients. Checkpoint ...

  • Magic™ Humanized IL-6R Immune Checkpoint Knock-In Mice

    Magic™ Humanized IL-6R Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Soluble cytokine receptors play pivotal roles in health and disease. Signaling of the IL-6 (cytokine interleukin-6) via its ligand, sIL-6R (soluble IL-6 receptor) is causative for the proinflammatory properties of IL-6 and appears to be an attractive...