Mode of Action (MOA) Determination for Fungi

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  • Published date: January 15, 2020
    • Shirley, New York, United States

Target deconvolution terms retrospective identification of the molecular targets that underlie the observed phenotypic responses. It is an important aspect of current drug discovery. Target deconvolution is important for elucidating the mode of action of antifungal drugs and greatly aid structure-activity relationship (SAR) studies and rational drug design. Chemical optimization can be conducted by the configuration of target­specific assays and target­specific side effects, like toxicity can be addressed and reduced. Creative Biolabs provides several techniques for target deconvolution, including affinity chromatography-based methods, expression-cloning-based methods, protein microarrays, reverse-transfected cell microarrays, and biochemical suppression.

Jerry Carter
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