Post Antifungal Effect (PAFE)

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  • Published date: January 15, 2020
    • Shirley, New York, United States

The post antifungal effect (PAFE) refers to growth suppression of surviving fungi following the removal of antifungals in the absence of host defense mechanisms. It is a phenomenon which is observed both in vitro and in vivo. Antifungals are capable of exerting many different effects on surviving fungi even though they are just transitorily exposed to the drug. The mechanisms of post antifungal effect include delayed recovery of enzyme and non-enzyme protein activities; changes in cell morphology, metabolism, growth and generation time; changes in cell receptors; susceptibility to phagocytosis; and altered susceptibility to an antifungal following re-exposure. PAFE is more enduring comparing the effect of changes in growth rate. https://www.creative-biolabs.com/drug-discovery/therapeutics/post-antifungal-effect-pafe.htm .

Jerry Carter
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