Protein/Peptide Crosslinking

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  • Published date: May 30, 2019
  • Modified date: October 17, 2019
    • Shirley, New York, United States

Crosslinking is a technique that covalently binds two or more biomolecules together to form conjugates with enhanced physical properties and/or biological functionalities. The structure of a functioning protein involves more than just the intramolecular covalent bonds, which results in challenging questions regarding the spatial orientation and non-covalent interactions of the protein. The dynamic nature of proteins in physiological environment makes it even difficult to determine the roles of individual amino acids in the chemical and biological properties of proteins. The ability to introduce modifications on protein structures is extremely useful as it allows for exploration of protein functions at sub-molecular level and the possibility of various applications such as producing protein-enzyme conjugates. In protein chemistry, crosslinking reagents are widely used to study intermolecular interactions and to construct new structures. Mechanistically, crosslinking strategies fall into three categories: chemical crosslinking, enzymatic crosslinking and photocrosslinking.

Anna Camp
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