Recombinant Human CD33 Protein(His tag), Biotinylated

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  • Published date: May 30, 2019
    • Shirley, New York, United States

Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). Biotinylated recombinant Human CD33 Protein (P20138) (Asp 18 - His 259) with a polyhistidine tag at the C-terminus was expressed in HEK293.

Anna Camp
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