PEGylation

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  • Published date: February 11, 2019
    • Shirley, New York, United States

Polyethylene glycol (PEG) modification, also known as molecular PEGylation, is a promising technology developed in the late 1970s and widely used to improve delivery in pharmaceutical applications. Most chemical drugs and proteins, peptides and other biologic drugs have their own shortcomings. Linking the therapeutic protein or small molecules with suitable length of PEG chain can lead to an obviously change in the activity, molecular mass or other property. Moreover, the modification of polyethylene glycol molecules contributes to a less chance of contact between the drug and the protease, which can achieve the effect of half-life increasing and solubility enhancement for drug compounds. Meanwhile, the PEGylation is also supposed to be an efficient strategy to reduce the immunogenicity for most of exogenous material and improve the pharmacokinetic and pharmacodynamics properties. In this case, the PEG modification technology has attracted increasing attention of many scientists and pharmaceutical manufacturers.

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https://www.bocsci.com/solutions/pegylation.htm

Alex Brown
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