Biology & Physiology

Listings
  • Isothermal Titration Calorimetry

    Isothermal Titration Calorimetry

    Biology & Physiology Shirley (New York) April 28, 2019 Check with publisher

    Isothermal titration calorimetry (ITC) is a gold standard physical technique used to determine the thermodynamic parameters of interactions in solution. This label free technique is based on the precise measurement of heat absorbed or generated durin...

  • GLP In Vivo ADME & PK Studies

    GLP In Vivo ADME & PK Studies

    Biology & Physiology Shirley (New York) January 28, 2019 Check with publisher

    Thorough characterization and in-depth study of PK, as well as absorption, distribution, metabolism, and excretion (ADME) properties, are critical in order to support vaccine discovery and development processes for the production of safer and more ef...

  • Fear Conditioning Test

    Fear Conditioning Test

    Biology & Physiology Shirley (New York) September 29, 2019 Check with publisher

    The contextual and cued fear conditioning test is one of the most widely used behavioral paradigms used to assess associative fear learning and memory in rodents. Creative Biolabs utilizes this test for evaluating drug compounds' ability to reverse d...

  • Magic™ Humanized CD86 Immune Checkpoint Knock-In Mice

    Magic™ Humanized CD86 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 29, 2019 Check with publisher

    Immune checkpoint blockade therapies have emerged as a promising alternative for cancer treatment and have resulted in significantly successful outcome of cancer patients compared to conventional chemotherapy. Immune checkpoint receptors like CD28 ha...

  • Magic™ Whole Fluorescent Cell Lines for Internalization Detection

    Magic™ Whole Fluorescent Cell Lines for Internalization Detection

    Biology & Physiology Shirley (New York) September 29, 2019 Check with publisher

    Generally speaking, there are 2 kinds of internalization formats: receptor-mediated and non-receptor-mediated. The former one is the most conventional internalization pattern. Upon binding with membrane receptors, the target molecule can translocate ...

  • Magic™ Humanized PD-1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Programmed death-1 (PD-1) is a costimulatory receptor that belongs to the B7/CD28 family. PD-1 is expressed on numerous immune cells such as activated T cells, natural killer (NK) cells, B cells and some myeloid cells. PD-1 regulates T-cell activatio...

  • Magic™ Humanized PD-L1/TIGIT Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/TIGIT Dual Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    PD-L1 (Programmed death-ligand 1), also known as CD274 (cluster of differentiation 274) or B7-H1 (B7 homolog 1), is type 1 transmembrane protein expressed on the tumor cell surface, or on neighboring host immune cells in the tumor microenvironment. T...

  • Magic™ Humanized PD-L1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    LAG-3 (lymphocyte-activation gene 3), also named as CD223 (cluster of differentiation 223), is an immune checkpoint receptor expressed on the cell surface of effector T cells and regulatory T cells (Tregs), and functions as a co-inhibitory molecule t...

  • Magic™ Humanized KDR Immune Checkpoint Knock-In Mice

    Magic™ Humanized KDR Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Over the past decades, significant progress has been made in profiling the KDR (VEGFR-2) specific intracellular signaling cascades resulting in proliferation, migration, survival and increased permeability, all of which contribute to the angiogenic r...

  • Magic™ Calcium-activated GPCR Stable Cell Lines

    Magic™ Calcium-activated GPCR Stable Cell Lines

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Cell signaling networks are complicated, often composed of multiple pathways acting in concert to regulate particular cellular functions precisely. Receptors are the core components of the signaling pathway for receiving and transducing the signals. ...

  • Magic™ DAG-activated GPCR Stable Cell Lines

    Magic™ DAG-activated GPCR Stable Cell Lines

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    GPCRs transduce signals through a variety of cascades and elicit diverse biophysical activities. Therapeutic compounds targeting GPCRs (no matter biologics and small molecules) are designed to interfere with GPCR functionalities via activating (agoni...

  • Magic™ cAMP-activated GPCR Cell Lines

    Magic™ cAMP-activated GPCR Cell Lines

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    In currently days, G-protein coupled receptors (GPCRs) represent one class of the most popular therapeutic targets. To accelerate and simplify research of GPCR biology and drug discovery, Creative Biolabs has established an innovative Magic™ platform...