Drug Development

Listings
  • Peptide Drug Bioconjugations

    Peptide Drug Bioconjugations

    Drug Development Shirley (New York) January 11, 2019 Check with publisher

    Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule. The field of bioconjugation has had a considerable impact on academic research, clinical diagnostics and the productio...

  • Metabolites Synthesis

    Metabolites Synthesis

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Metabolites of pharmaceutical compounds are pivotal to comprehending drug metabolism, potential drug interactions, and human drug metabolizing enzymes. Primary metabolites are synthesized by the cell because they are critical for biological growth li...

  • Reference Compounds Synthesis

    Reference Compounds Synthesis

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    ISO classifies materials into two groups as reference materials (RMs) and certified reference materials (CRMs). Reference materials (reference compounds), established for measuring the quality of analysis, are critical for any measurement process cha...

  • Impurities Synthesis

    Impurities Synthesis

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Impurity profile studies play significant roles in active pharmaceutical ingredient (API) development, which are closely related to the quality, safety and efficacy of drug products. And the impurity profile of API for drug products requires studying...

  • Intermediates Synthesis

    Intermediates Synthesis

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Owing to chirality is a pivotal factor in the safety and efficacy of many drug products, the production of single enantiomers of drug intermediates has become increasingly important in the pharmaceuticals industry. It has been seen that the increasin...

  • Building Block Synthesis

    Building Block Synthesis

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    During the last decades, the synthesis of building blocks has been explored by numerous groups, which are used in pharmaceutical products and other biologically active substances. Building blocks are important intermediates for many drugs and have ma...

  • API Synthesis

    API Synthesis

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Active Pharmaceutical Ingredient (API) is defined by U.S. Food & Drug Administration as: any substance or mixture of substances intended to be used as the active ingredient in the manufacture of a drug (medicinal) product. Such substances are int...

  • Physicochemical Prediction

    Physicochemical Prediction

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Physicochemical properties are key factors in quantitative structure–property relationship (QSPR) studies in controlling the interactions between xenobiotics and living organisms. Computational approaches for toxicity prediction therefore generally r...

  • Quantitative structure–activity relationship (QSAR)

    Quantitative structure–activity relationship (QSAR)

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Quantitative structure–activity relationship (QSAR) is a method to build computational models, which attempts to find a significant correlation in statistics between structure and function. In drug design, structure refers to the molecular property o...

  • Activity Prediction

    Activity Prediction

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    In drug discovery, researchers are not only interested in detecting active molecules, but also in determining the biological activity observed in a particular molecule. At the same time, it is useful to identify the most representative subset of mole...

  • Lead Optimization

    Lead Optimization

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Lead optimization is a diversified operation in drug discovery, in which the chemical structures of compounds or biologics are modified to improve target’s specificity, selectivity, pharmacodynamics, pharmacokinetic and toxicological properties to ge...

  • Hit to Lead

    Hit to Lead

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Hit to Lead also known as lead generation is a prerequisite for the construction of new drugs’ molecular structures and the key first step in the development of new drugs. This stage aims to obtain each hit series and try to produce more potent and s...