Expertise

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  • Expertise in genomics and transcriptomics

    Expertise in genomics and transcriptomics

    Data Analysis - Analytics August 24, 2015 Check with publisher

    I lead the Integrative Genomics of Ageing Group (http://pcwww.liv.ac.uk/~aging/), and I have extensive experience in data analysis and integration of multidimensional data. Although my lab’s research integrates different strategies, its focal point i...

Listings
  • Magic™ Humanized OX40 Immune Checkpoint Knock-In Mice

    Magic™ Humanized OX40 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Administration of anti-OX40 increases proliferation of peripheral blood CD4+ and CD8+ T cells, increases responses to recall and naïve reporter Ags, and increases endogenous tumor-specific immune responses. Several agonistic anti-OX40 antibodies are ...

  • Magic™ Humanized CD27 Immune Checkpoint Knock-In Mice

    Magic™ Humanized CD27 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    The activity of CD27 is restricted by the transient availability of its ligand CD70/TNFSF7, which is constitutively expressed on medullary thymic epithelial cells (mTECs) and dendritic cells. Apart from this, CD70/TNFSF7 is specifically expressed aft...

  • Magic™ Humanized SIRPα Immune Checkpoint Knock-In Mice

    Magic™ Humanized SIRPα Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    In a wide variety of preclinical models, therapies that block the CD47/SIRPα axis stimulate phagocytosis of cancer cells in vitro and anti-tumor immune responses in vivo. Nowadays, many therapeutics targeting the CD47/SIRPα axis are under preclinical...

  • Magic™ Humanized CD28 Immune Checkpoint Knock-In Mice

    Magic™ Humanized CD28 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    CD28 and CTLA4 are highly homologous and compete for the same ligands [B7-1 (CD80) and B7-2 (CD86)]. The affinity of CTLA4 binding to these ligands is higher than CD28, which enables CTLA4 to compete with CD28 for ligands and suppress effector T cell...

  • Magic™ Humanized CD137 Immune Checkpoint Knock-In Mice

    Magic™ Humanized CD137 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    CD137 is one of the tumor necrosis factor (TNF) receptor family member, which is also known as TNFRSF9 and 4-1BB. CD137 is expressed on activated T cells, while to a larger extent on CD8+ than on CD4+ T cells. Additionally, CD137 is also found on den...

  • Impurity Characterization and Management

    Impurity Characterization and Management

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Creative Biolabs has the experience of using analytical techniques to characterize impurities or contaminants and pays attention to the impurities that are called Potential Genotoxic Impurities (PGIs), which are known to be potential mutagens or carc...

  • Magic™ Humanized GITR Immune Checkpoint Knock-In Mice

    Magic™ Humanized GITR Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Glucocorticoid-induced TNFR-related protein (GITR) or activation-inducible TNFR family receptor (AITR), which is also known as a member of the tumor necrosis factor receptor superfamily (member 18 as TNFRSF18), is currently of great interest to resea...

  • DNA Microinjection

    DNA Microinjection

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Microinjection is a useful technique that plays an important part in the generation of genetically modified mouse and rat models. Different microinjection systems can exist, the construction and configuration of which directly depends on the type of ...

  • Magic™ Humanized TNF-α Immune Checkpoint Knock-In Mice

    Magic™ Humanized TNF-α Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Targeted immune checkpoint blockade augments anti-tumor immunity and induces durable responses in patients with melanoma and other solid tumors. Tumor necrosis factor (TNF or TNF-α) is a major pro-inflammatory cytokine involved in early The primary c...

  • Magic™ Humanized CD276 Immune Checkpoint Knock-In Mice

    Magic™ Humanized CD276 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Immune checkpoints refer to proteins that act as T cell receptor (TCR) co-signaling partners which deliver either positive or negative signals to T lymphocytes. Blocking the actions of the immune checkpoint receptors can produce a potent anti-tumor r...

  • Magic™ GPCR Stable Cell Lines For Antibody Function Study

    Magic™ GPCR Stable Cell Lines For Antibody Function Study

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Inspired by two signaling pathways involved in GPCR signaling pathways, Creative Biolabs has introduced an innovative anti-GPCR antibody function screening system in virtue of different fluorescent biosensor linked with the activity of 3 secondary me...

  • Magic™ cAMP-activated GPCR Cell Lines

    Magic™ cAMP-activated GPCR Cell Lines

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    In currently days, G-protein coupled receptors (GPCRs) represent one class of the most popular therapeutic targets. To accelerate and simplify research of GPCR biology and drug discovery, Creative Biolabs has established an innovative Magic™ platform...