Project Offers - Collaborations

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • Pharmacokinetic Assays

    Pharmacokinetic Assays

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Pharmacokinetics (PK) studies are of great importance in creating new therapeutic drugs, understanding both the beneficial and harmful effects of drugs, and guiding drug development experiments and trials. In PK assays, the applied assay method shoul...

  • Cassette Dosing Studies

    Cassette Dosing Studies

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Cassette dosing is an efficient technique mainly applied in drug discovery efforts of pre-clinical studies, in order to obtain pharmacokinetic data from multiple candidate drugs in a single experiment. Thus, a similar amount of information obtained f...

  • In Vitro ADME

    In Vitro ADME

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Creative Biolabs offers services in the application of in vitro experimental systems to evaluate drug absorption, distribution, metabolism, and excretion. Based on our state-of-the-art research, we seek to develop drugs by ADME studies. We are able t...

  • Mode of Action (MOA) Determination for Fungi

    Mode of Action (MOA) Determination for Fungi

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Recent antifungal drugs have many side effects which limit their clinical use. For instance, amphotericin B has severe acute and chronic toxicities, and azoles have a low susceptibility to fungal pathogens. To improve drugs' efficiency and reduce the...

  • In Vitro Pharmacodynamics

    In Vitro Pharmacodynamics

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Pharmacodynamics (PD) is the study of the biochemical, physiologic, and molecular effects of drugs on the body, and involves receptor binding, post-receptor effects, and chemical interactions. It is a study of how the drug affects the organism. It de...

  • Antifungal Synergistic and Antagonistic Effects Testing

    Antifungal Synergistic and Antagonistic Effects Testing

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Novel drugs and/or new approaches to combat infective fungi and overcome fungal resistance are urgently needed. Pay attention to the interactions between different drugs is an economical method. Creative Biolabs provides in vitro assays to measure th...

  • Parallel Artificial Membrane Permeability Assay (PAMPA)

    Parallel Artificial Membrane Permeability Assay (PAMPA)

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Passive diffusion is an important way for drug absorption. It influences drugs pass through the intestinal epithelium, the blood brain barrier or transport across cell membranes. The PAMPA model is an artificial in vitro model suitable for the passiv...

  • Apoptosis and Programmed Cell Death Assessment

    Apoptosis and Programmed Cell Death Assessment

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Apoptosis is a type of programmed cell death (PCD), which is defined as a highly regulated process of cell elimination. Key events of apoptotic cells involve cell shrinking, nuclear and chromosomal fragmentation, PARP cleavage, etc. Two major pathway...

  • Fc Profiling Services

    Fc Profiling Services

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Antibody fragment crystallizable (Fc) region plays a critical part in eliciting indirect target elimination including ADCC, ADCP, CDC, all of which compose vital functioning mechanisms of most therapeutic antibodies. Over the past decade, Fc region i...

  • Endocytosis and Internalization Potency Detection

    Endocytosis and Internalization Potency Detection

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    One important mechanism of action of therapeutic antibodies is to induce internalization and turnover of cell surface receptors, resulting in receptor down-modulation as well as antibody endocytosis. This receptor-mediated internalization exhibits gr...

  • Interference with Nucleic Acid Synthesis

    Interference with Nucleic Acid Synthesis

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Gene is the manipulator of life. It consists of a large number of nucleic acids and is responsible for the direction of metabolism throughout the life of a cell. They direct the synthesis of protein, control the production of enzymes, and are respons...

  • Light/Dark Box Test

    Light/Dark Box Test

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Creative Biolabs conducts a battery of anxiety behavioral tests to evaluate the potential therapeutic value and the anxiolytic activity of novel compounds. Specifically, the light/dark box test (LDB) is based on the innate aversion of rodents to brig...