Project Offers - Collaborations
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DrugAge database of compounds that increase lifespan
Biomedical Sciences Liverpool August 24, 2015 Check with publisherWe're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...
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Pharmacokinetic Assays
Biological Sciences Shirley (New York) November 28, 2019 Check with publisherPharmacokinetics (PK) studies are of great importance in creating new therapeutic drugs, understanding both the beneficial and harmful effects of drugs, and guiding drug development experiments and trials. In PK assays, the applied assay method shoul...
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Cassette Dosing Studies
Biological Sciences Shirley (New York) November 28, 2019 Check with publisherCassette dosing is an efficient technique mainly applied in drug discovery efforts of pre-clinical studies, in order to obtain pharmacokinetic data from multiple candidate drugs in a single experiment. Thus, a similar amount of information obtained f...
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In Vitro ADME
Biological Sciences Shirley (New York) November 28, 2019 Check with publisherCreative Biolabs offers services in the application of in vitro experimental systems to evaluate drug absorption, distribution, metabolism, and excretion. Based on our state-of-the-art research, we seek to develop drugs by ADME studies. We are able t...
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Mode of Action (MOA) Determination for Fungi
Biological Sciences Shirley (New York) November 28, 2019 Check with publisherRecent antifungal drugs have many side effects which limit their clinical use. For instance, amphotericin B has severe acute and chronic toxicities, and azoles have a low susceptibility to fungal pathogens. To improve drugs' efficiency and reduce the...
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In Vitro Pharmacodynamics
Biological Sciences Shirley (New York) November 28, 2019 Check with publisherPharmacodynamics (PD) is the study of the biochemical, physiologic, and molecular effects of drugs on the body, and involves receptor binding, post-receptor effects, and chemical interactions. It is a study of how the drug affects the organism. It de...
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Antifungal Synergistic and Antagonistic Effects Testing
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherNovel drugs and/or new approaches to combat infective fungi and overcome fungal resistance are urgently needed. Pay attention to the interactions between different drugs is an economical method. Creative Biolabs provides in vitro assays to measure th...
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Parallel Artificial Membrane Permeability Assay (PAMPA)
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherPassive diffusion is an important way for drug absorption. It influences drugs pass through the intestinal epithelium, the blood brain barrier or transport across cell membranes. The PAMPA model is an artificial in vitro model suitable for the passiv...
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Apoptosis and Programmed Cell Death Assessment
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherApoptosis is a type of programmed cell death (PCD), which is defined as a highly regulated process of cell elimination. Key events of apoptotic cells involve cell shrinking, nuclear and chromosomal fragmentation, PARP cleavage, etc. Two major pathway...
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Fc Profiling Services
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherAntibody fragment crystallizable (Fc) region plays a critical part in eliciting indirect target elimination including ADCC, ADCP, CDC, all of which compose vital functioning mechanisms of most therapeutic antibodies. Over the past decade, Fc region i...
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Endocytosis and Internalization Potency Detection
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherOne important mechanism of action of therapeutic antibodies is to induce internalization and turnover of cell surface receptors, resulting in receptor down-modulation as well as antibody endocytosis. This receptor-mediated internalization exhibits gr...
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Interference with Nucleic Acid Synthesis
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherGene is the manipulator of life. It consists of a large number of nucleic acids and is responsible for the direction of metabolism throughout the life of a cell. They direct the synthesis of protein, control the production of enzymes, and are respons...
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Light/Dark Box Test
Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisherCreative Biolabs conducts a battery of anxiety behavioral tests to evaluate the potential therapeutic value and the anxiolytic activity of novel compounds. Specifically, the light/dark box test (LDB) is based on the innate aversion of rodents to brig...
